Following our visit to the University of Cambridge last week, we have been asked to share details of an exciting new study. A research team there is investigating how mitochondria—the tiny “batteries” inside our cells—function in people with Prader–Willi Syndrome (PWS), and whether this could explain some of the symptoms experienced by those living with the condition.
Mitochondria generate the energy that keeps our bodies running. When they don’t work properly, cells struggle to produce enough energy, which can lead to fatigue, muscle weakness, and metabolic difficulties. Researchers at Cambridge are using advanced MRI scanning techniques to explore mitochondrial function in real time, aiming to uncover whether differences in energy production are linked to PWS.
Why this study matters
This research could help answer important questions:
- Do mitochondria work differently in people with PWS compared to those without?
- Could mitochondrial dysfunction explain some of the symptoms experienced by people with PWS?
- If so, could this open up new pathways for treatment and support?
By taking part, volunteers will be contributing to science that could make a real difference in understanding and managing PWS.
Who can volunteer?
For this study, the Researchers are looking for:
- Adults aged 18–35
- Ideally not currently taking medication
What’s involved?
Volunteers will spend a day at the University of Cambridge (9am – 4pm) and travel expenses will be reimbursed. The study includes:
- A non-invasive MRI scan (around 1.5 hours, with breaks)
- A series of tests and questionnaires about symptoms and health
- Optional: a muscle biopsy for those comfortable with this additional step
- Travel expenses reimbursed
If you’d like to learn more or volunteer, please contact the research team at: cuh.mitopws@nhs.net