Since its inception FPWR UK has funded several studies into advancing critical research into Prader Willi Syndrome (PWS). These studies have contributed much to the body of knowledge on PWS and furthering our aim of eliminating the main challenges of PWS and eventually finding a cure.
Click the link to access the study in full detail.
2026
£16,000 – IDENTIFYING IMPAIRED NEURAL PATHWAYS OF SATIATION FOR PRADER-WILLI SYNDROME (Dr. Cai is investigating why people with Prader-Willi syndrome do not appear to respond normally to the body’s natural “fullness” signals and exploring new ways to activate these pathways to help reduce hunger)
https://fpwr.org.uk/can-cck-help-us-understand-hunger-and-fullness-in-pws
£16,000 ALLELE-SPECIFIC MAGEL2 MOUSE MODELS TO DEFINE CIRCADIAN AND SLEEP MECHANISMS IN PWS AND SYS SYNDROMES (Dr. Liu hopes to uncover how the MAGEL2 protein helps control sleep and other daily biological rhythms, providing new insights into the sleep challenges experienced by people with Schaaf-Yang Syndrome and Prader-Willi Syndrome.)
https://fpwr.org.uk/understanding-sleep-in-prader-willi-syndrome-pws-and-schaaf-yang-syndrome-sys
£16,000 EPIGENETIC ACTIVATION OF THE PWS LOCUS IN POST-MITOTIC NEURONS (Dr. Gersbach is exploring ways to reactivate essential genes that are switched off in Prader-Willi syndrome, with the hope of developing effective treatments that can be used throughout life)
https://fpwr.org.uk/targeting-the-root-cause-of-prader-willi-syndrome
https://www.fpwr.org/fpwr-funded-projects/epigenetic-activation-of-the-pws-locus-in-post-mitotic-neurons
2025
Assessing DGKk dysregulation in Prader-Willi syndrome: https://www.fpwr.org/fpwr-funded-projects/assessing-dgkk-dysregulation-in-prader-willi-syndrome
2024
£25,000 Non-coding RNAs in neuronal differentiation and PWS:
https://www.fpwr.org/fpwr-funded-projects/non-coding-rnas-in-neuronal-differentiation-and-pws-year-2
£25,000 Obsessive-compulsive and psychotic-like behaviors across PWS subtypes: Developmental considerations:
FPWR Announces 1st Round of 2024 Grants
£15,000 Study into SYS and Magel 2:
2023
£10,000 Genetic Determinants of Behavioral, Physical, and Physiological Characteristics of PWS (fpwr.org)
2023 – £26,000 VNS4PWS –Exciting New Treatment May Reduce Disruptive Behaviors in PWS (fpwr.org)
2022
£60,000 Genetic Determinants of Behavioral, Physical, and Physiological Characteristics of PWS (fpwr.org)
2021
£20,000 How is the Epitranscriptomic Signature of Active AGRP Neurons Disrupted in PWS? (fpwr.org)
2020
£40,000 Long Non-Coding RNAs Transcribed From Prader-Willi syndrome Locus: Key Regulators of Gene Expression
2019
£77,200 Influences of Social Cognition and Reward on ASD Symptoms and Behaviour in PWS
2018
£84,000 Improving social functioning in Prader-Willi Syndrome (year 2)
This has now been developed as the BOSS (Building our Social Skills) course – a programme that helps individuals with PWS develop tooks to handle emotional and communication challenges. Please follow this link for more information: http://fpwr.org/boss-curriculum-lp
2016
£10,000 Wake promoting effects of oxytocin
£73,000 Recapitulating obesity and hyperphagia in novel adult-onset mouse models of Snord116 deletion
2015
£40,000 Oxytocin and the autonomic nervous system in Prader Willi Syndrome
£47,000 Training task switching to decrease temper outbursts in people with PWS